In
addition to interfering with topoisomerase enzyme II that is responsible for
condensing of chromatin, Doxorubicin being
a DNA intercalator, as a mechanism of cancer treatment,
they consequently inhibit DNMT1, the methyltransferase enzyme. When DNMT1 is
interfered with and consequently methylation of DNA, the genetic material becomes unstable and
transcription becomes asymmetrical, Apoptosis
of the cell is therefore induced.
