Skin from male mouse grafted on back of female. within 2 wks graft becomes necrotic and must be removed. what cells responsible

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25-05-2018
Biology

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Skin from male mouse grafted on back of female. within 2 wks graft becomes necrotic and must be removed. what cells responsible

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BioWizard BioWizard · Answer 1 · 2018-06-05T11:00:32+02:00

The correct answer is CD8+ T lymphocytes.

This process is known as graft rejection and it is defined as the immunological destruction of transplanted organs or tissues. The graft rejection may be based on both cell-mediated and antibody-mediated immunity against cells of the graft. When rejection occurs via cellular immunity, it is mediated by killer T cells (cytotoxic or CD8+ cells) which induce the apoptosis of target cells.